Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation. but whether post-transcriptional mechanisms can regulate this process is unknown. Here. we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. https://www.pomyslnaszycie.com/halloween-skull-bride-groom-cheap/