Limb-threatening or essential limb ischemia (CLI) is manifested by chronic (much more than two weeks) ischemic rest soreness, ischemic wounds or tissue decline, or gangrene in one or both legs. Ischemic rest suffering usually happens soon just after falling asleep; the client is awakened by burning pain or numbness from https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/