Pentobarbital will decrease the level or influence of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known. pentobarbital will decrease the level or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. fentanyl transdermal and pentobarbital both increase sedation. Avoid or Use Alternate Drug. ... https://is-nembutal-a-depressant94837.designi1.com/52518903/what-does-is-nembutal-a-depressant-mean