TH588 is nudix hydrolase spouse and children inhibitor that efficiently and selectively engages and inhibits the MTH1(IC50: five nM) in cells. They observed that Cas9-mediated base editing is a possible strategy to overcome CHB by permanently inactivating integrated HBV DNA and cccDNA with out double-strand breaks from the host genome. https://benjamink318afk2.wikirecognition.com/user